Evidence for Avian H9N2 Influenza Virus Infections among Rural Villagers in Cambodia
Identifieur interne : 000893 ( Main/Exploration ); précédent : 000892; suivant : 000894Evidence for Avian H9N2 Influenza Virus Infections among Rural Villagers in Cambodia
Auteurs : Patrick J. Blair [Cambodge] ; Shannon D. Putnam [Cambodge] ; Whitney S. Krueger [États-Unis] ; Channimol Chum [Cambodge] ; Thomas F. Wierzba [Cambodge] ; Gary L. Heil [États-Unis] ; Chadwick Y. Yasuda [Cambodge] ; Maya Williams [Cambodge] ; Matthew R. Kasper [Cambodge] ; John A. Friary [États-Unis] ; Ana W. Capuano [États-Unis] ; Vonthanak Saphonn [Cambodge] ; Malik Peiris [République populaire de Chine] ; Hongxia Shao [États-Unis] ; Daniel R. Perez [États-Unis] ; Gregory C. Gray [États-Unis]Source :
- Journal of infection and public health [ 1876-0341 ] ; 2013.
Abstract
Southeast Asia remains a critical region for the emergence of novel and/or zoonotic influenza, underscoring the importance of extensive sampling in rural areas where early transmission is most likely to occur.
In 2008, 800 adult participants from eight sites were enrolled in a prospective population-based study of avian influenza (AI) virus transmission where highly pathogenic avian influenza (HPAI) H5N1 virus had been reported in humans and poultry from 2006 to 2008. From their enrollment sera and questionnaires, we report risk factor findings for serologic evidence of previous infection with 18 AI virus strains.
Serologic assays revealed no evidence of previous infection with 13 different low-pathogenic AI viruses or with HPAI avian-like A/Cambodia/R0404050/2007(H5N1). However, 21 participants had elevated antibodies against avian-like A/Hong Kong/1073/1999(H9N2), validated with a monoclonal antibody blocking ELISA assay specific for avian H9.
Although cross-reaction from antibodies against human influenza viruses cannot be completely excluded, the study data suggest that a number of participants were previously infected with the avian-like A/Hong Kong/1073/1999(H9N2) virus, likely due to as yet unidentified environmental exposures. Prospective data from this cohort will help us better understand the serology of zoonotic influenza infection in a rural cohort in SE Asia.
Url:
DOI: 10.1016/j.jiph.2012.11.005
PubMed: 23537819
PubMed Central: 3612269
Affiliations:
- Cambodge, République populaire de Chine, États-Unis
- Floride, Iowa, Maryland
- College Park (Maryland), Iowa City
- Université de l'Iowa, Université du Maryland
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Putnam</name><affiliation wicri:level="1"><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff><country xml:lang="fr">Cambodge</country><wicri:regionArea>Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Krueger, Whitney S" sort="Krueger, Whitney S" uniqKey="Krueger W" first="Whitney S." last="Krueger">Whitney S. Krueger</name><affiliation wicri:level="2"><nlm:aff id="A2">College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Chum, Channimol" sort="Chum, Channimol" uniqKey="Chum C" first="Channimol" last="Chum">Channimol Chum</name><affiliation wicri:level="1"><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff><country xml:lang="fr">Cambodge</country><wicri:regionArea>Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Wierzba, Thomas F" sort="Wierzba, Thomas F" uniqKey="Wierzba T" first="Thomas F." last="Wierzba">Thomas F. 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Blair</name><affiliation wicri:level="1"><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff><country xml:lang="fr">Cambodge</country><wicri:regionArea>Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Putnam, Shannon D" sort="Putnam, Shannon D" uniqKey="Putnam S" first="Shannon D." last="Putnam">Shannon D. Putnam</name><affiliation wicri:level="1"><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff><country xml:lang="fr">Cambodge</country><wicri:regionArea>Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Krueger, Whitney S" sort="Krueger, Whitney S" uniqKey="Krueger W" first="Whitney S." last="Krueger">Whitney S. Krueger</name><affiliation wicri:level="2"><nlm:aff id="A2">College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Chum, Channimol" sort="Chum, Channimol" uniqKey="Chum C" first="Channimol" last="Chum">Channimol Chum</name><affiliation wicri:level="1"><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff><country xml:lang="fr">Cambodge</country><wicri:regionArea>Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Wierzba, Thomas F" sort="Wierzba, Thomas F" uniqKey="Wierzba T" first="Thomas F." last="Wierzba">Thomas F. Wierzba</name><affiliation wicri:level="1"><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff><country xml:lang="fr">Cambodge</country><wicri:regionArea>Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Heil, Gary L" sort="Heil, Gary L" uniqKey="Heil G" first="Gary L." last="Heil">Gary L. Heil</name><affiliation wicri:level="2"><nlm:aff id="A2">College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Yasuda, Chadwick Y" sort="Yasuda, Chadwick Y" uniqKey="Yasuda C" first="Chadwick Y." last="Yasuda">Chadwick Y. Yasuda</name><affiliation wicri:level="1"><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff><country xml:lang="fr">Cambodge</country><wicri:regionArea>Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Williams, Maya" sort="Williams, Maya" uniqKey="Williams M" first="Maya" last="Williams">Maya Williams</name><affiliation wicri:level="1"><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff><country xml:lang="fr">Cambodge</country><wicri:regionArea>Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Kasper, Matthew R" sort="Kasper, Matthew R" uniqKey="Kasper M" first="Matthew R." last="Kasper">Matthew R. Kasper</name><affiliation wicri:level="1"><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff><country xml:lang="fr">Cambodge</country><wicri:regionArea>Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Friary, John A" sort="Friary, John A" uniqKey="Friary J" first="John A." last="Friary">John A. Friary</name><affiliation wicri:level="2"><nlm:aff id="A2">College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Capuano, Ana W" sort="Capuano, Ana W" uniqKey="Capuano A" first="Ana W." last="Capuano">Ana W. Capuano</name><affiliation wicri:level="4"><nlm:aff id="A3">College of Public Health, University of Iowa, Iowa City, Iowa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Public Health, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Saphonn, Vonthanak" sort="Saphonn, Vonthanak" uniqKey="Saphonn V" first="Vonthanak" last="Saphonn">Vonthanak Saphonn</name><affiliation wicri:level="1"><nlm:aff id="A4">National Institute of Public Health/Ministry of Health, Phnom Penh, Cambodia</nlm:aff><country xml:lang="fr">Cambodge</country><wicri:regionArea>National Institute of Public Health/Ministry of Health, Phnom Penh</wicri:regionArea><wicri:noRegion>Phnom Penh</wicri:noRegion></affiliation></author><author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name><affiliation wicri:level="1"><nlm:aff id="A5">Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Shao, Hongxia" sort="Shao, Hongxia" uniqKey="Shao H" first="Hongxia" last="Shao">Hongxia Shao</name><affiliation wicri:level="4"><nlm:aff id="A6">VA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, College Park, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>VA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, College Park, MD</wicri:regionArea><placeName><region type="state">Maryland</region><settlement type="city">College Park (Maryland)</settlement></placeName><orgName type="university">Université du Maryland</orgName></affiliation></author><author><name sortKey="Perez, Daniel R" sort="Perez, Daniel R" uniqKey="Perez D" first="Daniel R." last="Perez">Daniel R. Perez</name><affiliation wicri:level="4"><nlm:aff id="A6">VA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, College Park, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>VA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, College Park, MD</wicri:regionArea><placeName><region type="state">Maryland</region><settlement type="city">College Park (Maryland)</settlement></placeName><orgName type="university">Université du Maryland</orgName></affiliation></author><author><name sortKey="Gray, Gregory C" sort="Gray, Gregory C" uniqKey="Gray G" first="Gregory C." last="Gray">Gregory C. Gray</name><affiliation wicri:level="2"><nlm:aff id="A2">College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author></analytic><series><title level="j">Journal of infection and public health</title><idno type="ISSN">1876-0341</idno><idno type="eISSN">1876-035X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Southeast Asia remains a critical region for the emergence of novel and/or zoonotic influenza, underscoring the importance of extensive sampling in rural areas where early transmission is most likely to occur.</p></sec><sec id="S2"><title>Methods</title><p id="P2">In 2008, 800 adult participants from eight sites were enrolled in a prospective population-based study of avian influenza (AI) virus transmission where highly pathogenic avian influenza (HPAI) H5N1 virus had been reported in humans and poultry from 2006 to 2008. From their enrollment sera and questionnaires, we report risk factor findings for serologic evidence of previous infection with 18 AI virus strains.</p></sec><sec id="S3"><title>Results</title><p id="P3">Serologic assays revealed no evidence of previous infection with 13 different low-pathogenic AI viruses or with HPAI avian-like A/Cambodia/R0404050/2007(H5N1). However, 21 participants had elevated antibodies against avian-like A/Hong Kong/1073/1999(H9N2), validated with a monoclonal antibody blocking ELISA assay specific for avian H9.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Although cross-reaction from antibodies against human influenza viruses cannot be completely excluded, the study data suggest that a number of participants were previously infected with the avian-like A/Hong Kong/1073/1999(H9N2) virus, likely due to as yet unidentified environmental exposures. Prospective data from this cohort will help us better understand the serology of zoonotic influenza infection in a rural cohort in SE Asia.</p></sec></div></front></TEI><affiliations><list><country><li>Cambodge</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Floride</li><li>Iowa</li><li>Maryland</li></region><settlement><li>College Park (Maryland)</li><li>Iowa City</li></settlement><orgName><li>Université de l'Iowa</li><li>Université du Maryland</li></orgName></list><tree><country name="Cambodge"><noRegion><name sortKey="Blair, Patrick J" sort="Blair, Patrick J" uniqKey="Blair P" first="Patrick J." last="Blair">Patrick J. Blair</name></noRegion><name sortKey="Chum, Channimol" sort="Chum, Channimol" uniqKey="Chum C" first="Channimol" last="Chum">Channimol Chum</name><name sortKey="Kasper, Matthew R" sort="Kasper, Matthew R" uniqKey="Kasper M" first="Matthew R." last="Kasper">Matthew R. Kasper</name><name sortKey="Putnam, Shannon D" sort="Putnam, Shannon D" uniqKey="Putnam S" first="Shannon D." last="Putnam">Shannon D. Putnam</name><name sortKey="Saphonn, Vonthanak" sort="Saphonn, Vonthanak" uniqKey="Saphonn V" first="Vonthanak" last="Saphonn">Vonthanak Saphonn</name><name sortKey="Wierzba, Thomas F" sort="Wierzba, Thomas F" uniqKey="Wierzba T" first="Thomas F." last="Wierzba">Thomas F. Wierzba</name><name sortKey="Williams, Maya" sort="Williams, Maya" uniqKey="Williams M" first="Maya" last="Williams">Maya Williams</name><name sortKey="Yasuda, Chadwick Y" sort="Yasuda, Chadwick Y" uniqKey="Yasuda C" first="Chadwick Y." last="Yasuda">Chadwick Y. Yasuda</name></country><country name="États-Unis"><region name="Floride"><name sortKey="Krueger, Whitney S" sort="Krueger, Whitney S" uniqKey="Krueger W" first="Whitney S." last="Krueger">Whitney S. Krueger</name></region><name sortKey="Capuano, Ana W" sort="Capuano, Ana W" uniqKey="Capuano A" first="Ana W." last="Capuano">Ana W. Capuano</name><name sortKey="Friary, John A" sort="Friary, John A" uniqKey="Friary J" first="John A." last="Friary">John A. Friary</name><name sortKey="Gray, Gregory C" sort="Gray, Gregory C" uniqKey="Gray G" first="Gregory C." last="Gray">Gregory C. Gray</name><name sortKey="Heil, Gary L" sort="Heil, Gary L" uniqKey="Heil G" first="Gary L." last="Heil">Gary L. Heil</name><name sortKey="Perez, Daniel R" sort="Perez, Daniel R" uniqKey="Perez D" first="Daniel R." last="Perez">Daniel R. Perez</name><name sortKey="Shao, Hongxia" sort="Shao, Hongxia" uniqKey="Shao H" first="Hongxia" last="Shao">Hongxia Shao</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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